解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2011.07.020
更新日期:2012-04-01 00:00:00
abstract::We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.03.011
更新日期:2012-03-01 00:00:00
abstract::Prior studies have suggested that the type of breast cancer influences the location of distant metastases ("organotropism") and that there may be discordance of estrogen receptor and human epidermal growth factor receptor 2 (Her2) expression between primaries and metastases. Our aims were to investigate the relationsh...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.05.009
更新日期:2012-03-01 00:00:00
abstract::Aberrant expression of the antiapoptotic protein BCL (B-cell lymphoma)-2 in neoplastic germinal centers is one of the diagnostic hallmarks of follicular lymphoma. If BCL-2 cannot be detected by immunohistochemistry, the distinction between florid follicular hyperplasia and follicular lymphoma might become a diagnostic...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2011.05.018
更新日期:2012-03-01 00:00:00
abstract::We report three cases of follicular dendritic cell sarcoma (FDCS) showing a hitherto undescribed histological pattern consisting of nodular tumor growth associated with small B lymphocytes. FDCS tumor cells consistently showed large epithelioid features and were intermingled with small lymphocytes in the nodules in tw...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.029
更新日期:2012-02-01 00:00:00
abstract::Cancer cells show a higher rate of anaerobic respiration than normal cells. The exact mechanisms for this higher glycolysis rate in cancer cells remain to be elucidated. The results of recent studies have indicated that p53, the most commonly mutated tumor suppressor gene, may have important functions in the regulatio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.04.021
更新日期:2012-02-01 00:00:00
abstract::This study explored the importance of hepatitis B virus infection in cholangiocarcinoma pathogenesis in northern China. The clinical data of 66 patients with cholangiocarcinoma were analyzed. The hepatitis B virus gene was amplified using nested polymerase chain reaction, and the hepatitis B virus-related antigen was ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.04.004
更新日期:2012-01-01 00:00:00
abstract::The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicula...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.035
更新日期:2012-01-01 00:00:00
abstract::Multifocal/multicentric breast cancers are common. However, investigations of biomarkers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 in individual tumor foci of such cancers are rare. This study was designed to evaluate the status of the hormone receptors, human epide...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.08.026
更新日期:2012-01-01 00:00:00
abstract::Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.017
更新日期:2011-12-01 00:00:00
abstract::Parakeratosis refers to incomplete maturation of epidermal keratinocytes, resulting in abnormal retention of nuclei in the stratum corneum. It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.005
更新日期:2011-12-01 00:00:00
abstract::The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.010
更新日期:2011-11-01 00:00:00
abstract::The current system of pathologic classification of human breast cancers does not take into account the biologic determinants of prognosis, nor is there a consensus regarding the progression from in situ to invasive carcinoma. The present study compared the molecular phenotypes of in situ and invasive components of bre...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.08.024
更新日期:2011-10-01 00:00:00
abstract::In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.12.011
更新日期:2011-10-01 00:00:00
abstract::Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.03.012
更新日期:2011-10-01 00:00:00
abstract::We present a rare case of unilateral intratesticular cystadenocarcinoma with mucinous differentiation in a 71-year-old male patient. The orchiectomy specimen revealed a 3.5-cm well to moderately differentiated cystic neoplasm with elongated fine papillary structures lined by columnar epithelium with alternating goblet...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.11.021
更新日期:2011-09-01 00:00:00
abstract::A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.12.002
更新日期:2011-09-01 00:00:00
abstract::Invasive mammary carcinoma with neuroendocrine differentiation has been controversial in terms of its definition and clinical outcome. In 2003, the World Health Organization histologic classification of tumors designated this entity as neuroendocrine carcinoma of the breast and defined mammary neuroendocrine carcinoma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.11.014
更新日期:2011-08-01 00:00:00
abstract::Snail1 and ZEB1 are transcriptional repressors that drive tumor initiation and metastasis in animal models. Snail1 and ZEB1 are frequently coexpressed in tumor cell lines, suggesting that these factors may cooperate to promote tumor progression. However, coexpression of these transcriptional repressors in primary huma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.11.004
更新日期:2011-08-01 00:00:00
abstract::Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.10.008
更新日期:2011-07-01 00:00:00
abstract::Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereby triggering hematopoietic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.09.012
更新日期:2011-05-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.032
更新日期:2011-04-17 00:00:00
abstract::Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic malignancy and is one of the best understood neoplasms, with relatively well-defined pathogenetic pathways, natural history, and tumor biology. Conventional clinical and pathologic parameters are widely used to grade and stage t...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2010.07.007
更新日期:2011-04-01 00:00:00
abstract::The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.07.019
更新日期:2011-04-01 00:00:00
abstract::Yes-associated protein, a downstream effector of the Hippo signaling pathway, has been linked to progression of non-small-cell lung carcinoma. The aim of this study was to investigate expression of Yes-associated protein in lung adenocarcinoma and squamous cell carcinoma. Associations of Yes-associated protein express...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.08.003
更新日期:2011-03-01 00:00:00
abstract::The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.05.025
更新日期:2011-02-01 00:00:00
abstract::Dermatofibrosarcoma protuberans is genetically characterized by the translocation t(17;22)(q22;q13) resulting in the PDGFB/COL1A1 fusion gene. Fluorescence in situ hybridization with specific probes enables a rapid detection of this gene. In this study, the presence of the translocation t(17;22)(q22;q13) by fluorescen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.07.015
更新日期:2011-02-01 00:00:00
abstract::Several matrix metalloproteinases (MMPs) are implicated in the degradation of the epithelial basement membrane (BM), invasiveness, and malignancy of endometrial and ovarian carcinomas. We have recently proposed a cooperative role for RUNX1/AML1 and ETV5/ERM in myometrial infiltration during endometrioid endometrial in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.01.025
更新日期:2011-01-01 00:00:00
abstract::Digitization of histologic slides is associated with many advantages, and its use in routine diagnosis holds great promise. Nevertheless, few articles evaluate virtual microscopy in routine settings. This study is an evaluation of the validity and diagnostic performance of virtual microscopy in routine histologic diag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.05.015
更新日期:2010-12-01 00:00:00
abstract::Intraductal papillary mucinous neoplasm is characterized by cystically dilated main and/or branch pancreatic duct with mucus. According to the degree of atypia, intraductal papillary mucinous neoplasm is classified into 3 groups: adenoma, borderline, and carcinoma. Furthermore, intraductal papillary mucinous neoplasm ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.019
更新日期:2010-11-01 00:00:00
abstract::The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.12.017
更新日期:2010-11-01 00:00:00
abstract::Topoisomerases are ubiquitous nuclear enzymes that regulate DNA structure in eukaryotic cells. The role of topoisomerase IIIβ, the newest member of the topoisomerase family, in the clinical outcome of breast cancer is still poorly understood. This study aims to investigate the immunoexpression of topoisomerase IIIβ in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.01.027
更新日期:2010-11-01 00:00:00
abstract::Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.021
更新日期:2010-10-01 00:00:00
abstract::Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.013
更新日期:2010-10-01 00:00:00
abstract::Myopericytoma is a rare, histologically distinctive tumor that shows evidence of differentiation toward perivascular myoid cells. Myopericytoma is largely considered a neoplasm of skin and soft tissues, with examples of this lesion involving visceral sites being extremely limited. We present the clinical and pathologi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.014
更新日期:2010-10-01 00:00:00
abstract::Paracoccidioidomycosis is a systemic mycosis with a geographic distribution that is limited to Central and South America; Brazil has the highest number of cases. Severe disseminated disease caused by paracoccidioidomycosis was observed in acquired immunodeficiency syndrome patients who live or have resided in endemic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.03.007
更新日期:2010-09-01 00:00:00
abstract::In this report, we present the clinicopathologic features of 13 cases of the invasive micropapillary variant of urothelial carcinoma. This is a rare and aggressive variant of bladder cancer recognized by the current World Health Organization classification of urologic tumors. The micropapillary component varied from 5...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.018
更新日期:2010-08-01 00:00:00
abstract::GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.014
更新日期:2010-07-01 00:00:00
abstract::Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.12.003
更新日期:2010-06-01 00:00:00
abstract::Epidermal growth factor receptor is a transmembrane receptor involved in oncogenesis, including the development of glioblastoma. We studied the prognostic significance of epidermal growth factor receptor amplification as determined by fluorescence in situ hybridization, quantitative polymerase chain reaction, and prot...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.09.020
更新日期:2010-06-01 00:00:00